Chemical Properties:
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moistureRuifu Chemical Supply Intermediates of Afatinib Afatinib CAS 439081-18-2 Afatinib Dimaleate CAS 850140-73-7 (S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2 (Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6 trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7 Diethylphosphonoacetic Acid CAS 3095-95-2 7-Fluoro-6-Nitroquinazolin-4(1H)-one CAS 162012-69-3 7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2 N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1 (S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine CAS 314771-76-1 (S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-Amine CAS 314771-88-5| Item | Specifications |
| Appearance | Light Yellow to Light Brown Powder |
| Identification (HPLC) | Retention Time of Sample Should Matches with Standard |
| Purity / Analysis Method | >99.0% (HPLC) |
| Melting Point | 300.0~303.0℃ |
| Water Content (K.F) | <0.50% |
| Residue on Ignition | <0.30% |
| Impurity 1 | <0.50% (7-Chloro-4-Hydroxyquinazoline CAS: 31374-18-2) |
| Impurity 2 | <0.50% (5,7-Dichloro-4[1H]quinazolinone) |
| Impurity 3 | <1.00% (7-Chloro-8-Nitro-4[1H]quinazolinone) |
| Other Single Impurity | <0.20% |
| Total Impurities | <1.00% |
| Heavy Metals (as Pb) | <20ppm |
| Infrared Spectrum | Conforms to Structure |
| Proton NMR Spectrum | Proton NMR Spectrum |
| Test Standard | Enterprise Standard |
| Usage | Intermediate of Afatinib, Afatinib Dimaleate |
Description:
Specifications:
Package & Storage:
| Chemical Name | 7-Chloro-6-Nitro-4-Hydroxyquinazoline |
| Synonyms | 7-Chloro-4-Hydroxy-6-Nitroquinazoline; 7-Chloro-6-Nitro-4-Quinazolinol; 7-Chloro-6-Nitro-4-Quinazolinone; 7-Chloro-6-Nitro-4(3H)-Quinazolinone; 7-Chloro-6-Nitro-3,4-Dihydroquinazolin-4-one; 7-Chloro-6-Nitroquinazolin-4(3H)-one |
| CAS Number | 53449-14-2 |
| CAT Number | RF-PI2030 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C8H4ClN3O3 |
| Molecular Weight | 225.59 |
| Sensitivity | Heat Sensitive |
| Solubility | Slightly Soluble in Dimethylformamide |
| Brand | Ruifu Chemical |
Advantages:
FAQ:
Application:
7-Chloro-6-Nitro-4-Hydroxyquinazoline (CAS: 53449-14-2) is an intermediate of Afatinib Dimaleate (CAS: 850140-73-7). Afatinib is an irreversible ErbB family of blockers that suppress information transmission and block the major pathways involved in cancer cell growth and division. Because ErbB family information transduction mechanism can be triggered by multiple homodimers and heterodimers, simultaneous inhibition of multiple ErbB family members (such as EGFR, HER2, ErbB3 and ErbB4) can effectively interrupt the downstream information transduction. Afatinib is used to treat a certain type of lung cancer (non-small cell lung cancer) that has spread to other parts of the body. It belongs to a class of drugs known as kinase inhibitors. It works by slowing or stopping the growth of cancer cells. It binds to a certain protein (epidermal receptor-EGFR) in some tumors.
